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KMID : 1137820170380030102
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의공학회지
2017 Volume.38 No. 3 p.102 ~ p.110
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Nanoparticle Inducing Device for Effective Drug Delivery System
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Lee Chong-Myeong
Han Hyeon-Ho
Jang Byong-Han
Oh Eun-Seol
Key Jae-Hong
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Abstract
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Cancer is one of the most challenging human diseases. Current clinical methods have limitations for early-stage cancer diagnosis and effective therapy. Moreover, current surgical methods to remove tumors are not precise enough and chemotherapy destroys normal tissues as well as malignant tumors, resulting in severe side effects such as hair loss, vomiting, diarrhea, and blood disorders. Recently, nanotechnology using nano-sized particles suggests advanced solutions to overcome the limitations. Various nanoparticles have been reported for more accurate diagnosis and minimized side effects. However, current nanoparticles still show limited targeting accuracy for cancer generally below 5% injection dosage. Therefore, herein we report a new nanoparticle inducing device(NID) to guide the nanoparticles externally by using both variable magnetic fields and blood flows. NID can be a promising approach to improve targeting accuracy for drug delivery using iron oxide nanoparticles.
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KEYWORD
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iron oxide nanoparticles, nanoparticle inducing device, drug delivery, cancer, magnetic guidance
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